A review on antacids therapy for peptic ulcer disease

Authors

B.Keerthi Student, Nalanda Institute of Pharmaceutical Sciences, Siddharth nagar, Kantepudi(V), Sattenapalli(M), Guntur(Dist)-522438,AP, India.
Author
Dr.D.Rama Brahma Reddy , Nalanda Institute of Pharmaceutical Sciences, Siddharth nagar, Kantepudi(V), Sattenapalli(M), Guntur(Dist)-522438,AP, India.
Author
CH.N.V.S.Mastan Rao , Nalanda Institute of Pharmaceutical Sciences, Siddharth nagar, Kantepudi(V), Sattenapalli(M), Guntur(Dist)-522438,AP, India.
Author
B.Yaswanth , Nalanda Institute of Pharmaceutical Sciences, Siddharth nagar, Kantepudi(V), Sattenapalli(M), Guntur(Dist)-522438,AP, India.
Author

DOI:

Keywords:

Antacids, peptic ulcer disease, gastric acid, aluminium hydroxide,calcium carbonate.

Abstract

Antacids appear to be effective ulcer healing agents with efficacies resembling those of other antiulcer drugs. In peptic ulcer disease, antacids present a therapeutic effect by neutralizing gastric acid and reducing acid delivery to the duodenum. Clinical impression strongly suggests that antacids relieve pain in peptic ulcer but objective confirmation is lacking. A low calorie, low fat, synthetic dietary product is suggested as a substitute for milk products in the treatment of certain patients with peptic ulcer. The effect of antacids on the stomach is due to partial neutralisation of gastric hydrochloric acid and inhibition of the proteolytic enzyme, pepsin. Antacids are commonly used self-prescribed medications. They consist of calcium carbonate and magnesium and aluminum salts in various compounds or combinations.